Does Pre-Diabetic mother play role in Sex Chromosome Abnormalities in IVF Embryos?

Glycated hemoglobin or HbA1c level measurement is a useful diagnostic screening method for diabetic patients. HbA1c level equal to or more than 6.5% means more than 48 mmol/mol indicates a diagnosis of diabetes mellitus; whereas, the HbA1c level between 5.7–6.4%  means between 39–46 mmol/mol is considered as a prediabetic condition.

Clinical experts found that the risk of miscarriage and congenital malformation correlates with the HbA1c level. Aneuploidy is a chromosomal defect within a cell. In the human body, 46 chromosomes are present, but 45 or 47 chromosomal development during fetal growth is considered as aneuploidy.

Recently clinical researchers from Philadelphia have declared that the probability of sex chromosome aneuploidies in embryos is double in pre-diabetic patients in comparison with embryos formed in patients who have normal levels of glycated hemoglobin.

Researchers included patients who had undergone IVF with pre-implantation genetic testing for aneuploidies to establish the fact. In this research, diabetic patients were not included to reduce the confusion during result analysis.

Embryos at their blastocyte stage were thoroughly analyzed from 393 patients. Among these study participants, 320 patients had a normal level of HbA1c, whereas the remaining 73 patients had their prediabetic stage as their HbA1c lied between the  39–46 mmol/mol.

The research findings reported a significant correlation between sex-chromosome aneuploidy with the pre-diabetic condition. But it is necessary to mention that no association with autosomal aneuploidies. Researchers had also reported that embryos of both non-diabetic patients and pre-diabetic patients have a 50% chance to develop non-sex chromosomal abnormality. But X and Y chromosomal abnormality is more frequent in the embryos developed among pre-diabetic patients than in embryos develops in non-diabetic patients.  It is necessary to mention that the maternal age and Follicle-stimulating hormone (FSH) and Anti-Mullerian Hormone (AMH) hormonal levels do not correlate with aneuploidy. The study data had revealed at the 75th annual Scientific Congress and Expo of the American Society for Reproductive Medicine, researchers from Northwell Fertility (NY).

Fertility experts commented on this study findings that both diabetic and pre-diabetic patients have a delicate effect on their reproductive system. Further detailed studies provide more detailed results. However, it is necessary to mention that both diabetic and pre-diabetic patients need counseling to provide confidence that positive effort possibly helps them to conceive normally and also can mitigate the associated problems. 

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296702/

https://www.fertstert.org/article/S0015-0282(19)30860-X/abstract

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About Ravi Sharma

Ravi Sharma is a self-motivated, successful entrepreneur and has a solid experience in the fertility segment. He is a pharmacy graduate with post-graduation in business administration and has 14 years of rich experience in the field of infertility segment. His most recent success includes the successful launch of the medical tourism company, ARTbaby, which offers treatment options for infertility, egg donation and surrogacy. He likes spending time with his family and writing about various aspects of IVF surrogacy and donating eggs. In 2011, he founded the Surrogacy and Egg Donation Centre. ARTbaby has been giving the greatest happiness to childless couples for about 8 years. ARTbaby is one of the leading agencies with the highest birth rate both in Georgia and India. We provide customers with complete information and help them offer the best possible conditions, offering the lowest price possible so that customers can witness the happiness they desire. ARTbaby has a wide range of surrogate mothers, egg donors, and sperm donor databases. This allows you to choose the desired type of appearance and specifications of the donor. We are associated with the best in vitro clinics in Georgia and abroad. Our main goal is to provide maximum comfort for potential parents. ARTbaby Agency offers the following procedures: IVF/ICSI SURROGACY EGG DONATION FROZEN EGGS EMBRYO DONATION MEDICAL TOURISM/REPRODUCTIVE TOURISM Georgia is a modern country where surrogacy and egg donations are allowed. Georgia attracts many tourists with its geographical and cultural uniqueness. Recently, medical tourism has developed in Georgia, including IVF. The advantage over other countries is a high technology, available qualified doctors and embryologists, legal framework and as well as low prices.

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