The Discovery and implementation of egg donation are magical moves in reproductive medical technology. Repeated unsuccessful IVF cycle failure by using the intended mother’s egg can be solved by opting for egg donation. Egg donation also gives the scope to enjoy motherhood for those who are suffering from genetic diseases. Despite many pros of egg donation, we cannot assure 100% successful results from this technique.
Certain factors influence the success rate of the egg donation process. Age of the egg donor, egg quality, embryo health, sperm quality, medication, implantation failure, uterine lining receptivity, unprotected sex, medication, and lifestyle practice are the considerable factors that influence egg donation success. Incorrect donor matching, non-conduction of certain medical tests such as immunology could be the reason for such an outcome.
Often the first attempt of IVF failed, but multiple attempts give a higher success rate. But the decision to opt for repeated IVF attempt completely depends upon the personal choice of the couple. One of the major reasons to stop repeated IVF treatment is medical expenditure. However, the emotional stressor is another cause to drop out from the repeated IVF treatment.
Currently, researchers are working to solve the repeated failure of the egg donated IVF cycle. Researchers found from their research that mitochondrial degeneration or faulty DNA mutation leads to defective embryo formation.
Stem cell therapy is an emerging medical technology; clinicians are working on this to resolve the poor quality egg issue in the IVF process. In this process, ovarian stem cells are collected from intended mothers. The stem cell containing mitochondria is injected into the old egg to make them young. The mechanism of this stem cell therapy is the supply energy to the old egg cells to make them viable. In this process, the intended mother can use their egg. This is a promising technology to treat poor quality egg issues in the IVF process.
Ovarian rejuvenation is another promising technique to boost the ovaries. In this process, folliculogenesis is restored to make the ovarian environment adequate for oocyte development. This evolving technology using biological therapy consists of autologous, natural, safe sources to restore endocrine homeostasis. Hormonal balance to retrieve the impaired ovarian function can boost the ovarian environment locally to generate good quality oocytes that provide successful reproductive outcomes.